Other Quantitative MRI
Magnetic resonance is a flexible and powerful tool that can be sensitised to provide quantitative information on a wide range of physiological and physical processes, in addition to providing exquisite anatomical detail. Examples of such information include:
Relaxation time mapping
Measurements of T1, T2 and T2* are often sensitive to disease, although the MRI-specific nature of the measurements can make specific interpretation challenging. Areas where relaxation times have been shown to be of use include myocardium, lung, cartilage and brain.
MR spectroscopy allows the identification of a range of metabolites, many of which are relevant to disease processes. Example proton spectrum metabolites include N-acetylaspartate (NAA - a neuronal marker), choline (a marker of cellular membrane turnover) and lactate (a product of anaerobic glycolysis).
Analysis of the size and shape of structures within MR images often provides essential information regarding disease status. Examples include the size of tumours, the thickness of the cerebral cortex, brain volume and joint morphology. Sensitive methods for quantifying changes in such parameters can help identify the impact of disease modifying interventions.
Bioxydyn's extensive experience across the range of MRI methods means that we can tailor imaging readouts to the needs of individual studies. This bespoke approach ensures that leading edge methods can be deployed in a robust operational environment to enrich preclinical and clinical studies.