Inflammation leads to abnormalities of microvascular function. Often tissue perfusion changes in the presence of inflammation, accompanied by increases in capillary permeability and oedema. We are able to quantify the microvascular status of inflamed tissue using dynamic contrast-enhanced MRI (DCE-MRI).
DCE-MRI has historically been most commonly used for quantifying tumour microvascular status in cancer. The same class of measurement methods is also effective for monitoring the effects of inflammation. The Bioxydyn team has extensive DCE-MRI experience in delivering DCE-MRI biomarkers for studies of lung inflammation (for example in asthma, smoking) and joint inflammation (including rheumatoid arthritis, osteoarthritis and psoriatic arthritis) in collaboration with Imorphics. Bioxydyn is also able to provide DCE-MRI analysis in inflammatory bowel disease.
In addition to Bioxydyn's offerings around DCE-MRI for assessment of inflammation, we partner with Imorphics to deliver quantitative measurements of additional aspects of joint disease, includiing automated RAMRIS (RAMRIQ) and morphological assessments. We also provide analysis of gut motility for IBD in collaboration with Motlient.