Effective neurological MRI is essential for characterising disease and monitoring progression and response to intervention. Our expertise in diffusion MRI and other quantitative MRI methods provides a unique opportunity for studying the impact of disease and treatment on tissue characteristics and function.
Diffusion MRI and Anatomical Connectivity Mapping
Diffusion MRI is sensitive to the cellular structure of the brain and is an established method for identifying changes in tissue integrity due to disease. Diffusion MRI can also provide information on the anatomical connections of the brain. Bioxydyn has developed the Anatomical Connectivity Mapping (ACM) technique to allow quantification of the strength of connections to any region of the brain. ACM has been used to show connection disruption in early Alzheimer's disease, multiple sclerosis and stroke. It has also shown sensitivity to thereaputic intervention in Alzheimer's.
Blood-brain barrier disruption
The blood-brain barrier (BBB) protects the brain from many pathogens and large molecules by providing a tight separation of the blood pool from the tissue extracellular space. Damage to the BBB is observed in many conditions, including multiple sclerosis, cancer and neuroinflammation. Bioxydyn's expertise in dynamic contrast-enhanced MRI (DCE-MRI) allows the integrity of the BBB to be quantified.
Regional and whole-brain atrophy is associated with a number of neurological conditions, and is of particular interest for assessing tissue loss associated with dementia. Bioxydyn's experience with state-of-the-art methods for quantifying tissue volumes allows precise assessment of atrophy using standard MRI protocols.